(E/Z)-BIO-acetoxime

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(E/Z)-BIO-acetoxime

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

740841-15-0

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品名称

GSK-3 Inhibitor X

产品介绍

(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) 是一种有效的选择性 GSK-3α/β 抑制剂，IC₅₀为 10 nM。(E/Z)-BIO-acetoxime 对GSK-3α/β具有超过CDK5/p25，CDK2/cyclin A和CDK1/cyclin B(IC₅₀=2.4, 4.3, 63 μM) 200 倍的选择性。

生物活性

(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selectiveGSK-3α/βinhibitor, with anIC₅₀of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity overCDK5/p25,CDK2/cyclin AandCDK1/cyclin B(IC₅₀=2.4, 4.3, 63 μM)^[1].

IC₅₀& Target^[1]

GSK-3α

10 nM (IC₅₀)

GSK-3β

10 nM (IC₅₀)

Cdk5/p25

2.4 μM (IC₅₀)

CDK2/cyclinA

4.3 μM (IC₅₀)

CDK1/cyclinB

63 μM (IC₅₀)

体外研究
(In Vitro)

E/Z)-BIO-acetoxime (compound 13) shows more than 200-flod selectivity for GSK-3α/β over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, with IC₅₀s of 0.01, 2.4, 4.3 and 63 μM, respectively^[1].

分子量

398.21

Formula

C₁₈H₁₂BrN₃O₃

CAS 号

740841-15-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.