CP-10 is aPROTACconnected by ligands forCereblonandCDK, with highly selective, specific, and remarkableCDK6degradation (DC₅₀=2.1 nM). It inhibits proliferation of several haematopoieticcancercells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressedCDK6^[1].

CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC₅₀: 50-80 fold)^[1].
CP-10 displays a cell inhibition potential in multiple myeloma cell MM.1S (IC₅₀≈10 nM) and mantle cell lymphoma cells (in Mino, IC₅₀≈8 nM)^[1].

871.94

Solid

C₄₄H₄₉N₁₃O₇

2366268-80-4

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

DMSO : 200 mg/mL(229.37 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。