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XL413 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
XL413 hydrochloride图片
CAS NO:2062200-97-7
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
BMS-863233 Hydrochloride
产品介绍
XL413 (BMS-863233) hydrochloride 是一种有效的,选择性的,ATP 竞争性的Cdc7抑制剂,IC50值为 3.4 nM,同时对 CK2 和 PIM1 的IC50值分别为 215 和 42 nM,对 pMCM 的EC50值为 118 nM。
生物活性

XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor ofCdc7, with anIC50of 3.4 nM, and also shows potent effect withIC50s of 215, 42 nM onCK2,PIM1, respectively, and anEC50of 118 nM on pMCM.

IC50& Target[1]

Cdc7

3.4 nM (IC50)

PIM1

42 nM (IC50)

CK2

215 nM (IC50)

体外研究
(In Vitro)

XL413 (BMS-863233) hydrochloride inhibits the cell proliferation (IC50=2685 nM), decreases cell viability (IC50=2142 nM) and elicits the caspase 3/7 activity (EC50=2288 nM) in Colo-205 cells. XL413 hydrochloride also significantly inhibits the anchorage-independent growth of colo-205 in soft agar (IC50=715 nM)[1].
XL413 hydrochloride shows cytotoxic effects on tumors, with IC50of 22.9 μM in HCC1954 cells and 1.1 μM in Colo-205 cells. XL413 hydrochloride induces apoptosis in the Colo-205 cells, but not in HCC1954 cells. XL413 is effective DDK inhibitors in vitro, with IC50of 22.7 nM. XL413 hydrochloride is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells[2].

体内研究
(In Vivo)

XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses, with no significant body weight loss[1].

分子量

326.18

性状

Solid

Formula

C14H13Cl2N3O2

CAS 号

2062200-97-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 10 mg/mL(30.66 mM;Need ultrasonic)

DMSO : 3.4 mg/mL(10.42 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.0658 mL15.3290 mL30.6579 mL
5 mM0.6132 mL3.0658 mL6.1316 mL
10 mM0.3066 mL1.5329 mL3.0658 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。