Tetrodotoxin (TTX), a highly potent and marine-derived neurotoxin, is a selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels. It reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels, blocking nerve and muscle action potentials. Although tetrodotoxin was discovered in these fish and found in several other animals, it is actually produced by certain infecting or symbiotic bacteria like Pseudoalteromonas, Pseudomonas, and Vibrio as well as other species found in animals. Tetrodotoxin shows antagonism of aconitine-induced cardiac toxicity, analgesic effects in mouse models of neuropathy and prolonged duration of local anesthesia in animals when combined with capsaicin. Tetrodotoxin also shows pH-dependent blockade of canine cardiac L-type Ca2+ (Cav1.x) channels, blocks primary reward in an animal study of drug-seeking lever pressing.

纯度：≥98%

CAS：4368-28-9