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CDK1-IN-5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CDK1-IN-5图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CDK1-IN-5 (10h) 是CDK1的选择性抑制剂,对 CDK1,CDK2 和 CDK5 的IC50值分别为 42.19,188.71 和 354.15 nM。CDK1-IN-5 通过影响细胞周期抑制癌细胞生长。CDK1-IN-5 可用于癌症的研究。
生物活性

CDK1-IN-5 (10h) is a selectiveCDK1inhibitor withIC50s of 42.19, 188.71 and 354.15 nM forCDK1,CDK2andCDK5, respectively. CDK1-IN-5 inhibits growth ofcancercells by affecting cell cycle. CDK1-IN-5 can be used for the research ofcancer[1].

IC50& Target

CDK1

42.19 nM (IC50)

CDK2

188.71 nM (IC50)

CDK5

354.15 nM (IC50)

体外研究
(In Vitro)

CDK1-IN-5 (0-10 μM; 24 h) inhibits the growth of various cancer cells[1].
CDK1-IN-5 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC50s of 42.19, 188.71 and 354.15 nM, respectively[1].
CDK1-IN-5 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC50s of 5649, 8945, 2538, 2417, 8546 and 8138 nM, respectively[1].
CDK1-IN-5 (0.73 μM; 24 h) decreases CDK1 protein level in virto and affects cell cycle[1].

Cell Proliferation Assay[1]

Cell Line:PDAC, melanoma, leukemia, colon, and breast cancer cell lines
Concentration:0-10 μM
Incubation Time:24 hours
Result:Inhibited cell growth of PDAC, melanoma, leukemia, colon and breast cancer cells over 62%, and inhibited MDA-PATC53 and PL45 cells with IC50s of 0.73 and 1 μM, respectively.

Western Blot Analysis[1]

Cell Line:MDA-PATC53 cell line
Concentration:0.73 μM
Incubation Time:24 hours
Result:Downregulated the CDK1 protein level compared to untreated cells.

Cell Cycle Analysis[1]

Cell Line:MDA-PATC53 cell line
Concentration:0.73 μM
Incubation Time:24 hours
Result:Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.
分子量

504.05

Formula

C27H26ClN5OS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.