SR-1277 is a potent, selective and ATP competitiveCK1δ/εinhibitor, withIC₅₀s of 49 nM and 260 nM, respectively. SR-1277 also inhibitsFLT3,CDK4/cyclin D1,CDK6/cyclin D3andCDK9/cyclin K, withIC₅₀s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research ofcancer^[1].

SR-1277 exhibits antiproliferative effects in A375 cells, with an EC₅₀of 22 nM^[1].

SR-1277 (1 mg/kg; i.v.) exhibits C_max(1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μMoh), T_1/2(1.42 h) and brain penetration (24%) in mice^[1].

477.50

C₂₁H₁₉N₉O₃S

1446715-47-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.