Glycyl H-1152 hydrochloride

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CAS NO:

913844-45-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Glycyl H-1152 hydrochloride 是 Rho-kinase 抑制剂 H-1152 dihydrochloride 的糖基衍生物。Glycyl H-1152 hydrochloride 抑制ROCKII，Aurora A，CAMKII和PKG，IC₅₀值分别为 0.0118、2.35、2.57 和 3.26 μM。Glycyl H-1152 hydrochloride 比 H-1152 dihydrochloride 具有更高的选择性。

生物活性

Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibitsROCKII,Aurora A,CAMKIIandPKG, withIC₅₀s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride^[1].

IC₅₀& Target^[1]

ROCKII

11.8 nM (IC₅₀)

Aurora A

2.35 μM (IC₅₀)

CaMK II

2.57 μM (IC₅₀)

PKG

3.26 μM (IC₅₀)

分子量

449.40

Formula

C₁₈H₂₆Cl₂N₄O₃S

CAS 号

913844-45-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.