EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor^[1]. Small molecule-drug conjugate (SMDC)^[2].

Folate receptor^[1]

The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50)^[1].

FR-positive KB cells are highly sensitive to EC0489 with an IC₅₀of 5 nM^[1].

EC0489 has a favorable toxicology profile in Rats. EC0489 (2, 3, and 4 μmol/kg) has antitumor activity against mice KB tumor models in a dose-dependent manner^[1].

2550.68

C₁₁₁H₁₅₆N₂₂O₄₃S₂

1096702-14-5

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