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Aplyronine A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aplyronine A图片
CAS NO:151923-84-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Aplyronine A 是一种特异性肌动蛋白解聚剂。 Aplyronine A 具有抗肿瘤和凋亡作用。 Aplyronine A 可用于癌症、肌肉收缩、细胞运动和细胞分裂的研究。
生物活性

Aplyronine A is a specificactin-depolymerizingagent. Aplyronine A has antitumor andapoptosiseffect. Aplyronine A can be used for the research ofcancerand muscle contraction, cell motility and cell division[1].

IC50& Target

IC50: 0.01 nM (HeLa S3 cells)[1].
EC50: 1.3 μM (F-actin)[1]

体外研究
(In Vitro)

Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with an IC50value of 0.01 nM[1].
Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC50value of 1.3 μM in vitro actin-depolymerizing assay[1].
Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells[1].
Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis[1].

Western Blot Analysis[1]

Cell Line:HeLa S3 cells
Concentration:0-1 μM
Incubation Time:0-2 h
Result:Induced the dephosphorylation of FAK in HeLa S3 cells.

Apoptosis Analysis[1]

Cell Line:HeLa S3 cells
Concentration:100 nM
Incubation Time:24 h
Result:Significantly reduced cellular viabilities in tumor cells and significant activation of caspase 3 in HeLa S3 cells.
体内研究
(In Vivo)

Aplyronine A (0.08 mg/kg) exhibits remarkable antitumor activities in vivo against P388 murine leukemia cells[1].

分子量

1076.44

Formula

C59H101N3O14

CAS 号

151923-84-1

结构分类
  • Alkaloids
  • Other Alkaloids
  • Others
来源

Aplysia kurodai

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.