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Trimethobenzamide hydrochloride(Ro 2-9578)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trimethobenzamide hydrochloride(Ro 2-9578)图片
CAS NO:554-92-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
200mg电议
500mg电议

产品介绍
Trimethobenzamide hydrochloride (Ro 2-9578) 是 D2 受体的阻滞剂。
Cas No.554-92-7
别名盐酸三甲氧苯酰胺,Ro 2-9578
Canonical SMILESO=C(NCC1=CC=C(OCCN(C)C)C=C1)C2=CC(OC)=C(OC)C(OC)=C2.Cl
分子式C21H29ClN2O5
分子量424.92
溶解度DMSO : ≥ 100 mg/mL (235.34 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1].

The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1].

[1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42.