CAS NO: | 164301-51-3 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Semapimod tetrahydrochloride (CNI-1493), an inhibitor ofproinflammatory cytokineproduction, can inhibitTNF-α,IL-1β, andIL-6. Semapimod tetrahydrochloride inhibitsTLR4signaling (IC50≈0.3 μM). Semapimod tetrahydrochloride inhibitsp38 MAPKand nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Semapimod tetrahydrochloride leads to a significant decrease of p38-MAPK phosphorylation in macrophages, proinflammatory gene expression of macrophage inflammatory protein-1alpha, interleukin-6, monocyte chemoattractant protein-1, and intercellular adhesion molecule-1, and neutrophil infiltration. Semapimod tetrahydrochloride completely abrogated nitric oxide production within the tunica muscularis[2]. | ||||||||||||||||
体内研究 (In Vivo) | Semapimod tetrahydrochloride (5 mg/kg; i.p; daily for 2 weeks) ameliorates endothelial dysfunction in Obese Zucker (OZ) rats[1].
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Clinical Trial | |||||||||||||||||
分子量 | 890.74 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C34H56Cl4N18O2 | ||||||||||||||||
CAS 号 | 164301-51-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 2.17 mg/mL(2.44 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |