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MeOSuc-Ala-Ala-Pro-Val-AMC
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MeOSuc-Ala-Ala-Pro-Val-AMC图片
CAS NO:72252-90-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
MeOSuc-Ala-Ala-Pro-Val-AMC 是人类白细胞和猪胰弹性蛋白酶的荧光底物(Km:362 μ;M,Ex=380 nm,Em=460 nm)。
Cas No.72252-90-5
别名N-甲氧琥珀酰基-丙氨酰-丙氨酰-脯氨酰-缬氨酸-7-氨基-4-甲基香豆素
Canonical SMILESCOC(CCC(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NC2=CC=C(C(C)=CC(O3)=O)C3=C2)=O)=O)=O)C)=O)C)=O)=O
分子式C31H41N5O9
分子量627.7
溶解度DMF: 20 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 16 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MeOSuc-Ala-Ala-Pro-Val-AMC (MeOSuc-AAPV-AMC) is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is avidly hydrolyzed by these elastases but not by cathepsin G. The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence in the presence of elastase. This peptidyl-AMC substrate detects as little as 11 pM human leukocyte elastase and 18 pM porcine pancreatic elastase.