Everolimus-d4 (RAD001-d4) is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally activemTOR1inhibitor. Everolimus binds toFKBP-12to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cellapoptosisandautophagy. Everolimus has potent immunosuppressive and anticancer activities^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

962.25

C₅₃H₇₉D₄NO₁₄

1338452-54-2

依维莫司 D4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.