Bcl-2-IN-10

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Bcl-2-IN-10

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2773354-28-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Bcl-2-IN-10 是一种有活性的Bcl-2抑制剂，可释放多达四个一氧化氮 (NO) 分子。Bcl-2-IN-10 对人类白血病、乳腺癌和肺癌等癌细胞具有细胞毒性。Bcl-2-IN-10 可诱导细胞凋亡 (apopotosis)，阻滞细胞周期在 G2/M 期，可用于癌症相关的研究。

生物活性

Bcl-2-IN-10 is an activeBcl-2inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities againstcancercells, such as human leukemia, breastcancerand lungcancer. Bcl-2-IN-10 induces cellapopotosisand arrest cell cycle of G2/M phase, and can be used in cancer-related research^[1].

IC₅₀& Target^[1]

Bax

体外研究
(In Vitro)

Steroid sulfatase-IN-2 (compound 1, 0-20 μM approximately, 72 h) inhibits different cancer cells with IC₅₀s ranging from 1.26 μM to 17.86 μM^[1].
Steroid sulfatase-IN-2 (1 μM, 5 h) releases up to four molecules of nitric oxide^[1].
Steroid sulfatase-IN-2 (8 μM, 8-72 h) induces leukemia cell CCRF-CEM apoptosis via MAPKs pathways, arrests cell in the G2/M phase, and increases ratio of Bax/Bcl-2^[1].

Apoptosis Analysis^[1]

Cell Line:	CEM cells
Concentration:	8 μM
Incubation Time:	8, 24, 48 or 72 h
Result:	Induced apoptosis in a time-dependent and dose-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:	CEM cells
Concentration:	8 μM
Incubation Time:	8, 24, 48 or 72 h
Result:	Arrested cell in the G2/M phase.

Western Blot Analysis^[1]

Cell Line:	CEM cells
Concentration:	0-8 μM
Incubation Time:	72 h
Result:	Increased the levels of JNK and p38, and the levels of phosphorylated JNK and p38. Decreased Bcl-2 level in a time- and dose-dependent manner, and increased pro-apoptotic Bax level.

分子量

635.50

Formula

C₂₂H₂₅N₁₁O₁₂

CAS 号

2773354-28-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.