Bcl-2-IN-9 是一种新型、促凋亡的Bcl-2抑制剂，IC50为 2.9 μM，细胞毒性低。Bcl-2-IN-9 通过下调 Bcl-2 表达介导癌细胞凋亡 (apoptosis)，并对白血病细胞具有高选择性。
| 生物活性 | Bcl-2-IN-9 is a novel proapoptoticBcl-2inhibitor withIC50value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediatesapoptosisby down-regulating expression ofBcl-2incancercells and has a high selectivity against leukemia cells[1]. |
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体外研究
(In Vitro) | Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) inhibits HL-60 cells in vitro[1].
Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) shows low cytotoxic effects against WI-38 cells with cell viability of 91%[1].
Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) displays a high selectivity against leukemia cells[1].
Bcl-2-IN-9 (compound 6e) (10 μM) mediates apoptotic by down-regulating expression of Bcl-2 and causing chromatin compaction and nuclear fragmentation[1].
Cell Viability Assay[1] | Cell Line: | HL-60 cells | | Concentration: | 1, 10, 20, 40 μM | | Incubation Time: | 48 hours | | Result: | Surpressed cell growth and viability to 28.9%. |
Cell Cytotoxicity Assay[1] | Cell Line: | WT-38 cells | | Concentration: | 10 μM | | Incubation Time: | 48 hours | | Result: | Low cytotoxic effects. |
Apoptosis Analysis[1] | Cell Line: | HL-60 cells | | Concentration: | 1, 10, 20, 40 μM | | Incubation Time: | 48 hours | | Result: | Caused chromatin compaction and nuclear fragmentation. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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