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Bax activator-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bax activator-1图片
CAS NO:1638526-94-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Bax activator-1 (compound 106) 是一种Bax激活剂,诱导 Bax 依赖性肿瘤细胞凋亡。
生物活性

Baxactivator-1 (compound 106) is aBaxactivator that induces Bax-dependent tumor cellapoptosis[1].

IC50& Target

Bax

 

体外研究
(In Vitro)

Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion[1].

Apoptosis Analysis[1]

Cell Line:Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells
Concentration:20 μM, 40 μM , 60 μM , 80 μM
Incubation Time:48 hours
Result:Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion.
体内研究
(In Vivo)

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice[1].

Animal Model:Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)[1]
Dosage:40 mg/kg
Administration:Given i.p., each day for 13 days
Result:Exhibited anti-tumor activity as a single-agent.
分子量

488.62

Formula

C29H36N4O3

CAS 号

1638526-94-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.