Apoptotic agent-3

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Apoptotic agent-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2482310-23-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Apoptotic agent-3 (compound 15f) 通过潜在的线粒体介导的 Bcl-2/Bax 通路和激活 caspase-3 途径促进凋亡。Apoptotic agent-3 具有抗增殖活性，可用于癌症研究。

生物活性

Apoptotic agent-3 (compound 15f) promotesapoptosisthrough the potential mitochondria-mediated Bcl-2/Bax pathway and activation of theCaspase 3pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used forcancerresearch^[1].

IC₅₀& Target^[1]

Caspase 3

Bcl-2

Bax

体外研究
(In Vitro)

Apoptotic agent-3 (compound 15f) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2 MCF-7 and WI-38 cells (normal human cells) with IC₅₀values of 1.62, 1.46, 2.04 and 117.9 μM, respectively^[1].
. Apoptotic agent-3 (compound 15f) (24 hours) (1.46 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 11.53 folds and 10 folds, respectively, and decreases the level of Bcl-2 by 3.8 folds^[1].

Cell Cycle Analysis^[1]

Cell Line:	HepG-2 cells
Concentration:	1.46 μM
Incubation Time:	24 hours
Result:	The percentage of cells in the G2-M phase increased while the percentage of cells in G1 phase and S phase decreased.

Apoptosis Analysis^[1]

Cell Line:	HepG-2 cells
Concentration:	1.46 μM
Incubation Time:	24 hours
Result:	Increased the early apoptosis ratio from 0.69% to 8.25% and increased the late apoptosis ratio from 0.32% to 13.05%.

分子量

511.60

Formula

C₃₁H₂₁N₅OS

CAS 号

2482310-23-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.