CYD-2-11

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CYD-2-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1425944-22-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CYD-2-11 是一种选择性的Bax激动剂，K_i值为 34.1 nM。CYD-2-11 诱导细胞凋亡，对 MDA-MB-231 和 MCF-7 乳腺癌细胞系具有抗增殖作用，IC₅₀值为 3.22 和 3.81 μM。CYD-2-11 在 MDA-MB-231 肿瘤模型中抑制肿瘤生长。CYD-2-11 可用于乳腺癌和肺癌的研究。

生物活性

CYD-2-11 is a selectiveBaxagonist with aK_ivalue of 34.1 nM. CYD-2-11 induces cellapoptosisand shows antiproliferative activity to breastcancerMDA-MB-231 and MCF-7 cell lines withIC₅₀values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lungcancer^[1]^[2].

体外研究
(In Vitro)

CYD-2-11 (0-100 μM; 48 h) shows anti-proliferation effects to breast cancer cells^[1].
CYD-2-11 (5 μM; 48 h) selectively binds to Bax protein and induces apoptosis in NSCLC and SCLC cell lines^[2].

Cell Proliferation Assay^[1]

Cell Line:	T47D, MCF-7, MDA-MB-231, MDA-MB-468 and MCF-10A cell lines
Concentration:	0.01, 0.1, 1, 5, 10 and 100 μM
Incubation Time:	48 hours
Result:	Inhibited cell proliferation of T47D, MCF-7, MDA-MB-231, MDA-MB-468 and MCF-10A cells with IC₅₀values of 4.37, 9.47, 3.81, 3.22 and 8.73 μM, respectively.

Apoptosis Analysis^[2]

Cell Line:	SCLC and NSCLC cell lines
Concentration:	5 μM
Incubation Time:	48 hours
Result:	Induced cell apoptosis in both SCLC and NSCLC cells with a higher effect than SMBA1.

体内研究
(In Vivo)

CYD-2-11 (20 mg/kg; i.p.; once daily for 7 days) inhibits tumor growth^[1].
CYD-2-11 (40 mg/kg; i.p.; once daily for 14 days) represses lung cancer growth and overcomes rapalog resistance with the combination of RAD001 (1 mg/kg) in murine lung cancer models^[2].

Animal Model:	Female nude mice with MDA-MB-231 tumor xenografts^[1]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection; 20 mg/kg; once daily for 7 days
Result:	Exhibited a 57% inhibition rate of MDA-MB-231 tumor growth in vivo.

分子量

358.39

Formula

C₂₂H₁₈N₂O₃

CAS 号

1425944-22-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.