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KIRA9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KIRA9图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
KIRA9 是一种有效的IRE1抑制剂 (INS-1 细胞中IC50=4.8 μM)。KIRA9 能够完全结合IRE1的 ATP 结合位点,可阻断内质网 (ER) 定位的 mRNA 衰减和细胞凋亡 (apoptosis)。
生物活性

KIRA9 is a potentIRE1inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay andapoptosis[1].

IC50& Target

IC50: 4.8 μM (IRE1) in INS-1 cells[1]

体外研究
(In Vitro)

KIRA9 (0-30 μM; 2 hours) blocks the autophosphorylation induced by conditional overexpression of IRE1α in INS-1 cells (IC50=4.8 μM)[1].
KIRA9 (20 μM; 2 hours) reduces the mRNA expression of Bloc1s1, Ins1 and Ins2 in INS-1 cells[1].
KIRA9 (20 μM; 2 hours) blunts IRE1α-dependent decay (RIDD) in ER-stressed INS-1 cells[1].
KIRA9 (20 μM; 1 hour) markedly reduces the generation of cleaved caspase-3 and shows significant cytoprotective efficacy[1].
KIRA9 (0-20 μM; 3 days) reduces XBP1s expression, plasma cell differentiation and IgM secretion in a dose-dependent manner[1].

Apoptosis Analysis

Cell Line:INS-1 cells[1]
Concentration:20 μM
Incubation Time:1 hour
Result:Markedly reduced the generation of cleaved caspase-3 and showed significant cytoprotective efficacy.

Cell Differentiation Assay

Cell Line:Mouse splenocytes (LPS-treated)[1]
Concentration:0, 1.25, 2.5, 5.0, 10 and 20 μM
Incubation Time:3 days
Result:Reduced XBP1s expression, plasma cell differentiation and IgM secretion in a dose-dependent manner.
分子量

572.60

Formula

C27H27F3N6O3S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.