MC-Sq-Cit-PAB-Dolastatin10 is adrug-linker conjugate for ADCwith potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via theADC linkerMC-Sq-Cit-PAB.

ADC1-2 (anti-CD22 10F4v3 LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in WSU-DLCL2 human diffuse large B-cell lymphoma tumors with IC50 of 0.385 nM, and ADC1-1 (anti-Napi2b 10H1 11.4B LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in human ovarian cancer IGROV-1 and OVCAR-3x2.1 with IC₅₀s of 3.19 nM, 1.52 nM, respectively^[1].

1338.72

C₇₀H₁₀₅N₁₂O₁₂S

1941168-65-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.