N3-PEG3-vc-PAB-MMAE is a synthesizeddrug-linker conjugate for ADCthat incorporates the MMAE (a tubulin inhibitor ) and 3-unit PEG linker. N3-PEG3-vc-PAB-MMAE shows potent antitumor activity.

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of Dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

1352.66

Solid

C₆₇H₁₀₉N₁₃O₁₆

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