N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

307.10

C₉H₁₁BrN₂O₅

57159-62-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.