CPDA 是一种新型强效 SH2 结构域的肌醇磷酸酶 2 (SHIP2) 抑制剂。
| Cas No. | 14593-25-0 |
| 别名 | 乙酸-4-[1-氯-2-(甲氨基)乙基]苯酯盐酸盐 |
| 化学名 | 4-[1-chloro-2-(methylamino)ethyl]-phenol 1-acetate, monohydrochloride |
| Canonical SMILES | CC(OC1=CC=C(C(Cl)CNC)C=C1)=O.Cl |
| 分子式 | C11H14ClNO2.HCl |
| 分子量 | 264.1 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 25 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CpdA is a non-steroidal selective glucocorticoid receptor modulator. It is an aziridine precursor that can infiltrate cells and is translocated to the nucleus. It inhibits glucocorticoid receptor dimerization, which prevents transcription of gene targets such as NF-κB and subsequent cytokines through transrepression. Studies have shown contradictory results for binding affinity of CpdA compared with dexamethasone that were either higher (4-fold, IC50 = 6.4 nM and 25.9 nM, respectively, in L929sA cells) or lower (63-fold, Kd = 81.8 nM and 1.29 nM, respectively, in BWTG3 cells) in whole cell binding assays. |
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