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(±)-2-propyl-4-Pentenoic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(±)-2-propyl-4-Pentenoic Acid图片
CAS NO:1575-72-0
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
(±)-2-Propyl-4-pentenoic acid (4-en-VPA) 是丙戊酸的主要毒性代谢物。
Cas No.1575-72-0
别名2-丙基-4-五烯酸,2-Allylpentanoic Acid, 4-ene VPA
化学名2-propyl-4-pentenoic acid
Canonical SMILESC=CCC(C(O)=O)CCC
分子式C8H14O2
分子量142.2
溶解度Slightly soluble in methanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid.[1] It undergoes β-oxidation to form reactive metabolites that induce hepatotoxicity in rats. 4-ene VPA is also neuroteratogenic, reducing forebrain size and inducing deformation of the neural tube in mouse embryos.[2]

Reference:
[1]. Tang, W., and Abbott, F.S. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its α-fluorinated analogue: Phase II metabolism and pharmacokinetics. Drug Metab. Dispos. 25(2), 219-227 (1997).
[2]. Gofflot, F., Nassogne, M.C., Etzion, T., et al. In vitro neuroteratogenicity of valproic acid and 4-en-VPA. Neurotoxicol. Teratol. 17(4), 425-435 (1995).