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Prostaglandin F1α
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Prostaglandin F1α图片
CAS NO:745-62-0
包装:100µg
市场价:1190元

产品介绍
Cas No.745-62-0
别名PGF1α
化学名9α,11α,15S-trihydroxy-prost-13E-en-1-oic acid
Canonical SMILESO[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@@H](CCCCCCC(O)=O)[C@@H](O)C1
分子式C20H36O5
分子量356.5
溶解度50 mg/ml in DMSO, 50 mg/ml in DMF, 50 mg/ml in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3]

Reference:
[1]. Moore, A., and Waring, C.P. Electrophysiological and endocrinological evidence that F-series prostaglandins function as priming pheromones in mature male Atlantic salmon (Salmo salar) PARR. J. Exp. Biol. 199(Pt 10), 2307-2316 (1996).
[2]. Balapure, A.K., Rexroad, C.E., Jr., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochem. Pharmacol. 38(14), 2375-2381 (1989).
[3]. Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship. Advances in Prostaglandin and Thromboxane Research 7, 969-980 (1980).