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3β-hydroxy-5-Cholestenoic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3β-hydroxy-5-Cholestenoic Acid图片
CAS NO:6561-58-6
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
Cas No.6561-58-6
化学名(3β)-3-hydroxy-cholest-5-en-26-oic acid
Canonical SMILES[H][C@]12[C@@]([C@@](CC[C@]3([H])[C@H](C)CCCC(C)C(O)=O)([H])[C@]3(C)CC2)([H])CC=C4C[C@@H](O)CC[C@@]41C
分子式C27H44O3
分子量416.6
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. 3β-hydroxy-5-Cholestenoic acid is a modulator of γ-secretase that decreases amyloid β (1-42) peptide (Aβ42; EC50 = 250 nM) and increases Aβ38 levels with no effect on total Aβ in CHO2B7 cells. It decreases endogenous murine Aβ42 production by 60 and 75% in mouse postnatal neuron-glia cultures at concentrations of 3 and 10 μM, respectively.