| Cas No. | 959417-21-1 |
| 别名 | 4-羟基格链孢酚 |
| 化学名 | 3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one |
| Canonical SMILES | CC1=C(C2=C(C(O3)=O)C(O)=CC(O)=C2)C3=C(O)C(O)=C1 |
| 分子式 | C14H10O6 |
| 分子量 | 274.2 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 uM under cell-free conditions. |
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