BI-409306

立即咨询

BI-409306

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1189767-28-9

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

BI-409306 (BI-409306) 是一种有效的选择性 PDE9A 抑制剂，IC50 为 52 nM，对其他 PDE 活性较弱，例如 PDE1A (IC50, 1.4 ⋼M), PDE1C (IC50, 1.0 μ M); M)、PDE2A、PDE3A、PDE4B、PDE5A、PDE6AB、PDE7A 和 PDE10A（IC50 均 >10 μ；M）； BI-409306 可用于研究中枢神经系统疾病的记忆增强。

Cas No.	1189767-28-9
别名	BI-409306
Canonical SMILES	O=C1C2=C(N(C3CCOCC3)N=C2)NC(CC4=CC=CC=N4)=N1
分子式	C₁₆H₁₇N₅O₂
分子量	311.34
溶解度	DMSO : ≥ 75 mg/mL (240.89 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 uM), PDE1C (IC50, 1.0 uM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all >10 uM); BI-409306 can be used in the research of memory enhancement in CNS disorders. BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 uM), PDE1C (IC50, 1.0 uM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all >10 uM), and has no obvious effect on 95 non-PDE targets at 10 uM. BI-409306 enhances long-term potentiation (LTP) in rat hippocampal slices[1]. References: [1]. Cornelia Dorner-Ciossek, et al. BI 409306, a novel phosphodiesterase 9A inhibitor, part I: potency, selectivity and in-vitro functional characterization on synaptic plasticity. International Congress on Schizophrenia Research.