N3-PEG3-CH2CH2-Boc is acleavable3 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1]. N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

303.35

Liquid

C₁₃H₂₅N₃O₅

252881-73-5

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