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Aminooxy-PEG2-azide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aminooxy-PEG2-azide图片
CAS NO:1043426-13-6
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1 g电议

产品介绍
Aminooxy-PEG2-azide 是一种PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。Aminooxy-PEG2-azide 也是一种不可降解 (non-cleavable) 的含 2 个单元 PEG 的ADC linker,可用于合成抗体偶联药物 (ADC)。
生物活性

Aminooxy-PEG2-azide is a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs[1]. Aminooxy-PEG2-azide is also anon-cleavable2 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)[2].

IC50& Target[1][2]

PEGs

 

Non-cleavable

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

分子量

190.20

性状

Liquid

Formula

C6H14N4O3

CAS 号

1043426-13-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)