DBCO-NHCO-PEG4-amine is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. DBCO-NHCO-PEG4-amine is acleavableADC linkerused to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB–MMAE and DBCO-TRX–MMAE with EC₅₀s of 280 nM and 22 nM in SKBR3 cells, respectively)^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

523.62

C₂₉H₃₇N₃O₆

1255942-08-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.