Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis ofantibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1]<

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

539.58

Solid

C₂₈H₃₃N₃O₈

187223-15-0

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