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N-Boc-PEG5-bromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Boc-PEG5-bromide图片
CAS NO:1392499-32-9
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1 g电议

产品介绍
N-Boc-PEG5-bromide 是一种PROTAC连接桥,属于 PEG 类和 Alkyl/ether 类。N-Boc-PEG5-bromide 可用于合成一系列 PROTAC 分子。N-Boc-PEG5-bromide 是一种可降解 (cleavable) 的ADC连接桥,用于抗体药物结合物 (ADCs) 的合成。
生物活性

N-Boc-PEG5-bromide is a PEG/Alkyl/ether-basedPROTAClinkercan be used in the synthesis ofPROTACs. N-Boc-PEG5-bromide is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)[1].

IC50& Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

400.31

性状

Liquid

Formula

C15H30BrNO6

CAS 号

1392499-32-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month