| CAS NO: | 10129-56-3 |
| 包装: | 50mg |
| 市场价: | 3014元 |
| Cas No. | 10129-56-3 |
| 别名 | Α-(三氯甲基)-4-吡啶乙醇 |
| 化学名 | 1,1,1-trichloro-3-pyridin-4-ylpropan-2-ol |
| Canonical SMILES | C1=CN=CC=C1CC(C(Cl)(Cl)Cl)O |
| 分子式 | C8H8Cl3NO |
| 分子量 | 240.52 |
| 溶解度 | <12.03mg/ml in 1eq. HCl |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PETCM is an activator of caspase-3 [1]. Caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. Sequential activation of caspases plays an important role in cell apoptosis. In HeLa S-100 cell cytosol, PETCM activated caspase-3 in a dose-dependent way and induced apoptosome formation. PETCM (0.2 mM) caused Apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. Also, PETCM function required dATP. The activation effect of PETCM on caspase-3 was independent of PHAP proteins. When inhibited the activation activity of the PHAP proteins, PETCM reversed the suppression. When added to Q30 (Apaf-1/procaspase-9) plus cytochrome c and 10 μM dATP, recombinant PHAPI activated caspase-3. The activity was inhibited by recombinant ProT. While, PETCM reversed the inhibitory effect of ProT. PHAPI didn’t affect apoptosome formation and activated caspase-9 and Apaf-1, which were associated with apoptosome. ProT efficiently blocked formation of apoptosome and PETCM relieved this effect [1]. Reference: |
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