R18 是 14-3-3 的肽拮抗剂，KD 为 70-90 nM。 R18 有效阻断 14-3-3 与激酶 Raf-1（14-3-3 的生理配体）的结合，并有效消除 14-3-3 对磷酸酶诱导的 Raf-1 失活的保护作用。
| Cas No. | 211364-78-2 |
| 别名 | PHCVPRDLSWLDLEANMCLP |
| 化学名 | (3S,4Z,6S,7Z,9S,10Z,12S,13Z,15S,16Z,18S,19Z,21S,22Z,24S)-12-((1H-indol-3-yl)methyl)-18-(carboxymethyl)-24-((1Z,3S,4Z,6S,7Z,9S,10Z,12R,13Z,15S)-15-((S)-2-carboxypyrrolidine-1-carbonyl)-1,4,7,10,13-pentahydroxy-6-(2-hydroxy-2-iminoethyl)-12-(mercaptomethyl) |
| Canonical SMILES | CC(C[C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@]2([H])CCCN2)([H])CC3=CN=CN3)([H])CS)([H])C(C)C)=O)([H])CCCNC(N)=N)([H])CC(O)=O)([H])CC |
| 分子式 | C101H157N27O29S3 |
| 分子量 | 2309.69 |
| 溶解度 | Soluble to 1 mg/ml in Water |
| 储存条件 | Desiccate at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Antagonist of 14.3.3 proteins (KD≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. Induces apoptosis. |
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