CHM 1 是一种微管去稳定剂，可抑制微管蛋白聚合。 CHM 1 是一种针对人肝细胞癌的有效和选择性的抗有丝分裂抗肿瘤活性。 CHM 1 通过激活 Cdc2 激酶活性在人肝细胞癌细胞中通过 G2-M 期阻滞诱导生长抑制和细胞凋亡。
| Cas No. | 154554-41-3 |
| 别名 | NSC656158 |
| 化学名 | 6-(2-fluorophenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one |
| Canonical SMILES | C1OC2=C(O1)C=C3C(=C2)C(=O)C=C(N3)C4=CC=CC=C4F |
| 分子式 | C16H10FNO3 |
| 分子量 | 283.25 |
| 溶解度 | <7.08mg/ml in Water |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerizationin vitroandin vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells. |
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