| CAS NO: | 481-42-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 25mg | 电议 |
| Cas No. | 481-42-5 |
| 别名 | 白花丹素; 2-Methyljuglone |
| 化学名 | 5-hydroxy-2-methylnaphthalene-1,4-dione |
| Canonical SMILES | CC1=CC(=O)C2=C(C1=O)C=CC=C2O |
| 分子式 | C11H8O3 |
| 分子量 | 188.18 |
| 溶解度 | ≥ 6.35mg/mL in DMSO, ≥ 25.75 mg/mL in EtOH with ultrasonic |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 11.69 μM for A549 cells Plumbagin, a quinonoid constituent isolated from the root of Plumbago zeylanica L., has been shown to exert anticarcinogenic, antiatherosclerotic, and antimicrobial effects. In vitro: Plumbagin exhibited effective cell growth inhibition via inducing cancer cells to undergo G2/M phase arrest and apoptosis. Blockade of cell cycle was associated with increased levels of p21 and reduced amounts of Cdc2, Cdc25C and cyclinB1. Plumbagin treatment also found to enhance the levels of inactivated phosphorylated Cdc2 and Cdc25C. Blockade of p53 activity partially decreased plumbagin-induced apoptosis and G2/M arrest, indicating it might be operated by p53-dependent and independent pathway [1]. In vivo: To determine whether plumbagin inhibited the in vivo tumor growth, A549 cells were injected into nude mice. Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/day, where around 80% reductions in tumor size were observed, in contrast with mice treated with the vehicle. No sign of toxicity was observed in plumbagin-treated mice as judged by monitoring body weight [1]. Clinical trial: N/A Reference: |
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