您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > MIRA-1
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
MIRA-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MIRA-1图片
CAS NO:72835-26-8
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
MIRA-1 是一种马来酰亚胺类似物。 MIRA-1 可通过恢复 p53 依赖性转录反式激活诱导突变 p53 细胞凋亡。 MIRA-1 具有抗癌活性。
Cas No.72835-26-8
别名NSC 19630
化学名1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione
Canonical SMILESCCC(=O)OCN1C(=O)C=CC1=O
分子式C8H9NO4
分子量183.16
溶解度18.3mg/mL in ethanol, or in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 μM in vitro).1 Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner.[1] At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone , arrested tumor growth in a mouse xenograft model of multiple myeloma.[2]

Reference:
[1]. Bykov, V.J.N., Issaeva, N., Zache, N., et al. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. The Journal of Biological Chemisty 280(34), 30384-30391 (2005).
[2]. Saha, M.N., Chen, Y., Chen, M.H., et al. Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents. British Journal of Cancer 110(9), 2224-2231 (2014).