| CAS NO: | 72-54-8 |
| 包装: | 250mg |
| 市场价: | 514元 |
| Cas No. | 72-54-8 |
| 别名 | 4,4-滴滴滴,4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane |
| Canonical SMILES | ClC1=CC=C(C(C(Cl)Cl)C2=CC=C(Cl)C=C2)C=C1 |
| 分子式 | C14H10Cl4 |
| 分子量 | 320 |
| 溶解度 | Chloroform: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | p,p'-DDD is a metabolite of the organochlorine pesticide DDT. It is an agonist at estrogen receptor α (ERα) and ERβ, increasing transactivation with 20% relative effective concentrations (REC20) of 3.2 and 2.4 µM, respectively, in CHO-K1 cells expressing the human receptors. It inhibits DHT-induced androgen receptor transcription with a 20% relative inhibitory concentration (RIC20) of 0.71 µM. p,p'-DDD increases apoptosis in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 100 and 150 µg/ml. Blood levels of p,p'-DDD and the level of PBMC apoptosis are increased in children exposed to DDT compared with unexposed children. It is not considered lethal to hamsters (LD50 = ~5,000 mg/kg) but is to rats (LD50 = 3,750 mg/kg). |
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