N-Boc-N-bis(PEG4-OH) is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. N-Boc-N-bis(PEG4-OH) is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

469.57

C₂₁H₄₃NO₁₀

2093154-01-7

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