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Bis-PEG17-NHS ester
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bis-PEG17-NHS ester图片
CAS NO:2221948-93-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Bis-PEG17-NHS ester 是一种PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Bis-PEG17-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG17-NHS ester 是一种可降解 (cleavable) 的ADC连接桥,用于抗体药物结合物 (ADCs) 的合成。
生物活性

Bis-PEG17-NHS ester is a PEG/Alkyl/ether-basedPROTAClinkercan be used in the synthesis ofPROTACs. Bis-PEG17-NHS ester is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)[1].

IC50& Target[1]

PEGs

 

Alkyl/ether

 

Cleavable

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

1061.13

Formula

C46H80N2O25

CAS 号

2221948-93-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.