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Aminooxy-PEG2-alcohol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aminooxy-PEG2-alcohol图片
CAS NO:185022-12-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Aminooxy-PEG2-alcohol 是一种不可降解 (non-cleavable) 的含 2 个单元 PEG 的ADC linker,可用于合成抗体偶联药物 (ADC)。Aminooxy-PEG2-alcohol 也是一种PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。
生物活性

Aminooxy-PEG2-alcohol is anon-cleavable2 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs[2].

IC50& Target[1][2]

PEGs

 

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

分子量

121.14

Formula

C4H11NO3

CAS 号

185022-12-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.