您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Propargyl-PEG4-thiol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Propargyl-PEG4-thiol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Propargyl-PEG4-thiol图片
CAS NO:1347750-80-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Propargyl-PEG4-thiol 是一种PROTAC连接桥,属于 PEG 类。Propargyl-PEG4-thiol 可用于合成一系列 PROTAC 分子。Propargyl-PEG4-thiol 是一种不可降解 (non-cleavable) 的ADC连接桥,用于抗体药物结合物 (ADCs) 的合成。
生物活性

Propargyl-PEG4-thiol is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. Propargyl-PEG4-thiol is anon-cleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)[1].

IC50& Target[1]

Non-cleavable

 

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

248.34

Formula

C11H20O4S

CAS 号

1347750-80-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.