Tr-PEG2-OH is a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1]. Tr-PEG2-OH is also anon-cleavable2 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

348.43

C₂₃H₂₄O₃

105589-77-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.