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cis-4-Hydroxy-D-proline hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
cis-4-Hydroxy-D-proline hydrochloride图片
CAS NO:77449-94-6
包装与价格：
包装价格(元)
1 g电议
5 g电议
10 g电议
50 g电议

产品介绍
cis-4-Hydroxy-D-proline (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。cis-4-Hydroxy-D-proline (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
生物活性

cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis ofantibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs[1][2].

IC50& Target

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

分子量

167.59

性状

Solid

Formula

C5H10ClNO3

CAS 号

77449-94-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)