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Azido-PEG4-CH2-Boc
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azido-PEG4-CH2-Boc图片
CAS NO:864681-04-9
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
Azido-PEG4-CH2-Boc 是一种可降解 (cleavable) 的含 4 个单元 PEG 的ADC linker,可用于合成抗体偶联药物 (ADC)。Azido-PEG4-CH2-Boc 也是一种PROTAC linker,属于 PEG 和 Alkyl/ether 类,可用于合成 PROTAC 分子。
生物活性

Azido-PEG4-CH2-Boc is acleavable4 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-basedPROTAClinkerthat can be used in the synthesis ofPROTACs[2].

IC50& Target[1][2]

PEGs

 

Alkyl/ether

 

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

分子量

333.38

性状

Liquid

Formula

C14H27N3O6

CAS 号

864681-04-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month