| CAS NO: | 551-15-5 |
| 包装: | 20mg |
| 市场价: | 1145元 |
| Cas No. | 551-15-5 |
| 别名 | 甘草苷 |
| 化学名 | (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydrochromen-4-one |
| Canonical SMILES | C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O |
| 分子式 | C21H22O9 |
| 分子量 | 418.39 |
| 溶解度 | DMSO : 150 mg/mL (358.52 mM) |
| 储存条件 | Store at 2-8℃, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Liquiritin, a flavonoid isolated from Glycyrrhiza, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo[1]. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity[2]. Liquiritin can target the residues Ala-27, Val-29, Ala-25, and Asn-56 of AKR1C1[1]. Liquiritin (50 μM; 6 hours) results in 85.00% of reduction in progesterone metabolism, which is mediated by Aldo-keto reductase family 1 member C1 (AKR1C1) enzymatic activity in HEC-1-B cells[1]. Liquiritin (100 μM) increases glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells[2]. References: |
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