Boc-NH-PEG4-CH2CH2NH2 acleavable5 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

336.42

Liquid

C₁₅H₃₂N₂O₆

811442-84-9

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)