H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis ofantibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1][2

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

203.24

Solid

C₉H₁₇NO₄

45120-30-7

Room temperature in continental US; may vary elsewhere.

DMSO : 10 mg/mL(49.20 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。