SC239 is acleavable2-aminophenyl hemiasterlin drug-linker. SC239 can be as the drug-linker for ADC^[1].

SC239 is composed of a tubulin-targeting 3-aminophenyl hemiasterlin warhead,SC209(HY-144880), and a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)^[1].
The SC239 drug-linker is conjugated via a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)^[1].
SC239 conjugates exhibits better cytotoxic activity on Igrov1 cells which have lower expression levels of FolRα^[1].

1181.42

C₆₅H₈₄N₁₀O₁₁

1977557-97-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.